A comprehensive overview of the biologic properties of the etiologic viral agent, its clinico-pathological manifestations, the epidemiology of its infection, and present and future therapeutic and preventive options, revised (first edition, 1987) in accordance with a vast amount of new knowledge. New chapters have been added on viral cofactors in the pathogenesis of HIV disease; virologic and biologic features of HIV-2; simian retroviruses; care of the adult patient with HIV infection; ophthalmologic aspects of HIV infection; gastrointestinal manifestations of AIDS; occupational issues related to the HIV epidemic; oral lesions associated with HIV infection; immunizations, vaccine-preventable diseases, and HIV infection; and AIDS and the ethics of prevention, research, and care.